DHT is highly protective to the kidney and an elevated estrogen:androgen ratio is destructive to the kidney ( R ). involuntary muscle spasms, loss of muscle tone, increased body weight ( R ).diminished libido, erectile dysfunction, ejaculatory complaints, penile discomfort, loss of scrotal sensitivity, scrotal discomfort, loss of pubic hair, increased sperm density and gyno ( R ).insomnia, obstructive sleep apnea ( R), panic attacks, brain fog, suicidal idealization, slow cognition, anhedonia (a sign of elevated serotonin and low dopamine).dry skin or thinning of the skin, weight gain, elevated glucose and lipids and worsening of insulin sensitivity ( R).Additional side effects of finasteride include: It scrambles your hormones, libido and cognition all over the place, right into the gutters, and leaves you feeling like an empty dysfunctional husk. Many of the benefits of testosterone, such as enhanced insulin sensitivity, reduced catabolism, higher dopamine, increased thyroid hormone production, are mediated by DHT, and blocking DHT production prevents those effects/benefits. aldosterone → 5α-dihydroaldosterone, which increases the excretion of salt, the opposite of aldosterone.cortisol → 5α-dihydrocortisol (for the deactivation of cortisol).deoxycorticosterone → dihydrodeoxycorticosterone (DHDOC).progesterone → α-dihydroprogesterone (a very important neuroactive steroid and precursor to allopregnanolone).Bile also acts as an anti-bacterial and anti-microbial substance which keeps the gut clean and prevents SIBO and SIFO. synthesis of bile (5β-R specifically), which is essential for the digestion of fat and absorption of fat-soluble vitamins.What few people know is that there are 5β-R and 3 types of 5α-R enzymes and that they’re not only involved in the conversion of testosterone to DHT, but also in the: So let’s discuss what the drug, finasteride, does in the first place.įinasteride is a 5-alpha reductase inhibitor and this blocks the conversion of testosterone to DHT.
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